Hunting the CoV

Proteins are not stagnant—they wiggle and fold and unfold to take on numerous shapes. We need to study not only one shape of the viral spike protein, but all the ways the protein wiggles and folds into alternative shapes in order to best understand how it interacts with the ACE2 receptor, so that an antibody can be designed. Low-resolution structures of the SARS-CoV spike protein exist and we know the mutations that differ between SARS-CoV and 2019-nCoV. Given this information, we are uniquely positioned to help model the structure of the 2019-nCoV spike protein and identify sites that can be targeted by a therapeutic antibody. We can build computational models that accomplish this goal, but it takes a lot of computing power.

(Source: https://foldingathome.org/2020/02/27/foldinghome-takes-up-the-fight-against-covid-19-2019-ncov/)

You can share computer time too.

Hideously Ugly

Jun 13, 1862: Saw Millais’ “Carpenter’s Shop” at Ryman’s. It is certainly full of power, but hideously ugly: the faces of the Virgin and Christ being about the ugliest.

I found this quote in Lewis Carroll’s Diaries on Twitter.

And I found the following quote from Charles Dickens in Pre-Raphernalia, Raine Szramski‘s blog with “Pre-Raph Sketchbook Cartoons”.

You behold the interior of a carpenter’s shop. In the foreground of that carpenter’s shop is a hideous, wry-necked, blubbering, red-headed boy, in a bed-gown, who appears to have received a poke in the hand, from the stick of another boy with whom he has been playing in an adjacent gutter, and to be holding it up for the contemplation of a kneeling woman, so horrible in her ugliness, that (supposing it were possible for any human creature to exist for a moment with that dislocated throat) she would stand out from the rest of the company as a Monster, in the vilest cabaret in France, or the lowest ginshop in England.

Two almost naked carpenters, master and journeyman, worthy companions of this agreeable female, are working at their trade; a boy, with some small flavor of humanity in him, is entering with a vessel of water; and nobody is paying any attention to a snuffy old woman who seems to have mistaken that shop for the tobacconist’s next door, and to be hopelessly waiting at the counter to be served with half an ounce of her favourite mixture. Wherever it is possible to express ugliness of feature, limb, or attitude, you have it expressed. Such men as the carpenters might be undressed in any hospital where dirty drunkards, in a high state of varicose veins, are received. Their very toes have walked out of Saint Giles’s.

 

Perhaps Dickens initially saw the reproduction of Millais’ painting in the Illustrated London News (1850-05-11) and couldn’t forget that first impression. It seems that the engraver of the reproduction was a bit biased against Millais’ Carpenter’s Shop. (Twitter)


 

Whether ugly or not, Henry Holiday probably liked the painting of his teacher. He might have alluded to Millais’s Christ in the House of His Parents when he illustrated Lewis Carroll’s The Hunting of the Snark.

 

Category: Christ in the House of his Parents

 
2019-06-14, updated 2020-01-29

What – me worry?


Source for “Alfred E. Neuman”: en.wikipedia.org/wiki/File:Mad30.jpg

After a Butcher/Jowett comparison I run into a page published by Arthur Neuendorffer. (Art perhaps is in Oxford what Alois Kabelschacht is in room 354 of the Max Planck Institute for Physics in Munich.) Art discovered a resemblance between Henry Holiday’s depiction of The Butcher in Lewis Carroll’s The Hunting of the Snark and Alfred E. Neuman. He wrote: “When Mad Magazine was sued for copyright infringement, one defense it used was that it had copied the picture from materials dating back to 1911.” Incidentially, my first copy of the The Hunting of the Snark was an American edition published in 1911.

 
It seems, though, that Alfred E. Neuman and the Butcher are quite distant relatives:

I met the Snark in 2005

Before my Snark hunt started in 2008, I mainly focused on Henry Holiday’s illustration to the 5th fit in Lewis Carroll’s The Hunting of the Snark. Since 2005 (as a member of a works council specialized on OHS issues) I used that illustration as a depiction of improvable workplace design. I also inserted the illustration into a Wikipedia article in 2008. Probably from there it was copied into another Wikipedia article in 2012. That one again inspired a Forbes article about well-being in the workplace in 2013.

In 2008 I read Carroll’s and Holiday’s complete tragicomedy. Then I made an incidental discovery.

A Snark Excerpt as Graph


The image visualizes hypergraph properties of a part (lines 547 to 556) of Lewis Carroll’s The Hunting of the Snark. (I fixed the transposition error “Page 18” in the original image. In the 1st 1876 Snark edition it’s page 81.)

Image source:
Ronald Haentjens Dekker and David J. Birnbaum.
“It’s more than just overlap: Text As Graph.”
Presented at Balisage: The Markup Conference 2017,
Washington, DC, August 1 – 4, 2017.
In Proceedings of Balisage: The Markup Conference 2017.
Balisage Series on Markup Technologies, vol. 19 (2017).
https://doi.org/10.4242/BalisageVol19.Dekker01.

A remark which I received from David J. Birnbaum: Gijs Brouwer implemented the visualization, and Astrid Kulsdom transcribed the information based on the data model inside the application. Gijs’s animated version of the image is available at https://github.com/HuygensING/TAG/blob/master/snark-fly.mp4.

Page 81 visualization | Print/Mobile | EPUB | Twitter | Facebook

Happy Chinese New Year



 

Update 2019-06-11

Holiday’s Butcher and Millais’ Raleigh

But perhaps Holiday’s ruff – and the pose of the Fit Five drawing – was inspired by the Elizabethan drama inherent in Millais’ Boyhood of Raleigh, (1869).

Louise Schweitzer, One Wild Flower (2012)

 
more

 
2017-09-04, updated 2019-01-05